June 1, 2003Journal of Biological ChemistryOpen Access

Human Prorenin Has “Gate and Handle” Regions for Its Non-proteolytic Activation

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Population

Inactive recombinant human prorenin

Design

Preclinical

Authors

FSFmiaki SuzukiGifu University MHMakoto HayakawaGifu University TNTsutomu NakagawaToyonaka Municipal Hospital

Discussion

Member takes

Implication

May inform prorenin-targeted modulators; leaves open translation to human cardiovascular disease.

Structured PICO

Population

Inactive recombinant human prorenin

Intervention

Incubation with five kinds of antibodies (anti-01/06, anti-07/10, anti-11/26, anti-16/26, and anti-27/41) designed from the tertiary structure of predicted prorenin, and acid activation at pH 3.3

Outcome

Binding specificities, equilibrium dissociation constants, and non-proteolytic activation of proreninsurrogate

The identification of specific 'gate' and 'handle' regions in human prorenin provides mechanistic insights into its non-proteolytic activation.

Cite This Study

Suzuki et al. (2003) studied this question.

synapsesocial.com/papers/6a70ca04a528af2d65c3bd89 https://doi.org/10.1074/jbc.m302579200

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Human Prorenin Has “Gate and Handle” Regions for Its Non-proteolytic Activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Human Prorenin Has “Gate and Handle” Regions for Its Non-proteolytic Activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider