Population
Human plasma prorenin (in vitro model)
Comparison
Incubation with nonpeptide high-affinity active… vs Native inactive prorenin, low pH exposure, and…
Design
Preclinical
Authors
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May alter prorenin conformation in plasma; leaves open relevance to in vivo activation or renin inhibitor effects.
Renin inhibitors can induce a nonproteolytic conformational change in prorenin, exposing its active site and suggesting a model for substrate-mediated prorenin activation in vivo.
Derkx et al. (1992) studied this question.
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