Key result
Therapeutic drug monitoring followed by adherence counseling significantly reduced systolic blood pressure by 46 mm Hg in nonadherent patients compared to 12 mm Hg in adherent patients (p<0.01).
Why the study?
Adherence to medications is a major clinical challenge in treating hypertension, and therapeutic drug monitoring reliably detects nonadherence in apparent resistant hypertension.
Does therapeutic drug monitoring improve blood pressure control in patients with resistant hypertension?
Cohort (n=183)
No
Does therapeutic drug monitoring improve blood pressure control in patients with resistant hypertension?
Answers are grounded in this paper and cite their sources.
Therapeutic drug monitoring is a practical and cost-effective tool to identify nonadherence and facilitate significant blood pressure reductions in resistant hypertension.
To the Editor: Adherence to medications is a major challenge clinicians often face in treating hypertension. An increasing number of studies show therapeutic drug monitoring (TDM) is reliable for detecting medication nonadherence in patients who seem to have resistant hypertension (RH) [(1,2)][1
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Brinker et al. (2013) conducted a cohort in Resistant Hypertension (n=183). Therapeutic drug monitoring (TDM) and adherence counseling vs. Adherent patients and untested patients was evaluated on Reduction in systolic blood pressure at second follow-up (46 ± 10 mm Hg vs 12 ± 17 mm Hg reduction, p=<0.01). Therapeutic drug monitoring followed by adherence counseling significantly reduced systolic blood pressure by 46 mm Hg in nonadherent patients compared to 12 mm Hg in adherent patients (p<0.01).
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