August 1, 2001Arteriosclerosis Thrombosis and Vascular Biology

NO-Dependent Vasorelaxation Is Impaired After Gene Transfer of Inducible NO-Synthase

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Why the study?

Does gene transfer of iNOS impair NO-dependent vasorelaxation in rabbit carotid arteries?

Population

Rabbit carotid arteries (in vitro and in vivo)

Comparison

Gene transfer of iNOS using an adenoviral vector… vs Control virus (AdCMVBglII)

Design

Preclinical

Authors

CGCarol A. GunnettUniversity of Iowa DLDonald D. LundUniversity of Oxford YCYi ChuRutgers, The State University of New Jersey

Discussion

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Implication

iNOS expression may impair endothelial function; hypothesis-generating for its role in human vascular disease.

Structured PICO

Does gene transfer of iNOS impair NO-dependent vasorelaxation in rabbit carotid arteries?

Population

Rabbit carotid arteries (in vitro and in vivo)

Intervention

Gene transfer of iNOS using an adenoviral vector containing cDNA for murine iNOS (AdCMViNOS)

Comparator

Control virus (AdCMVBglII)

Outcome

NO-dependent relaxation and contraction responses to various stimuli (e.g., acetylcholine, KCl, phenylephrine)surrogate

Expression of iNOS per se impairs NO-dependent relaxation in blood vessels, providing a mechanistic link between proinflammatory stimuli and endothelial dysfunction.

Cite This Study

Gunnett et al. (2001) studied this question.

synapsesocial.com/papers/6a70d305febe604dd70997f4 https://doi.org/10.1161/hq0801.093509

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NO-Dependent Vasorelaxation Is Impaired After Gene Transfer of Inducible NO-Synthase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

NO-Dependent Vasorelaxation Is Impaired After Gene Transfer of Inducible NO-Synthase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider