Why the study?
Does captopril prevent myocardial hypertrophy in STZ-diabetic rats as assessed by MRI?
Population
Streptozotocin-diabetic male Wistar rats and age-matched controls
Comparison
Captopril started immediately after induction of… vs Untreated STZ-diabetic rats and age-matched…
Design
Preclinical
Follow-up
Scanned at 16 weeks of age
Authors
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Captopril prevented diabetes-induced biventricular hypertrophy in rats; leaves open translation to human diabetic cardiomyopathy.
Does captopril prevent myocardial hypertrophy in STZ-diabetic rats as assessed by MRI?
Captopril prevents the development of biventricular myocardial hypertrophy in a rat model of diabetes, as demonstrated by a novel quantitative MRI technique.
Al‐Shafei et al. (2002) studied this question.
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