Population
Chinese hamster ovarian cells and a fibroblast cell line from mice with a genetic inactivation of Galpha…
Design
Preclinical
Authors
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Challenges canonical AT1 signaling models; leaves open relevance to human cardiovascular disease.
This study provides the first evidence that a seven-transmembrane receptor can activate intracellular tyrosine kinase pathways independently of a G-protein-coupled rise in intracellular calcium.
Doan et al. (2001) studied this question.
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