Population
Chinese hamster ovary cells stably expressing a truncated mutant of the angiotensin II receptor devoid of…
Comparison
Angiotensin II stimulation vs Full-length AT1A receptor
Design
Preclinical
Authors
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AT1A desensitization proceeds without internalization or C-terminal tail; challenges consensus on GPCR phosphorylation-directed uncoupling and leaves open distinct mechanisms for cardiovascular research.
Truncation of the AT1A receptor's carboxyl-terminal 45 amino acids inhibits its endocytosis but does not prevent rapid desensitization, suggesting a distinct desensitization mechanism compared to other G-protein-coupled receptors.
Thomas et al. (1995) studied this question.
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