Why the study?
Do triiodothyronine and angiotensin II increase Type 1 deiodinase activity and mRNA expression in cultured rat cardiac myocytes?
Population
Cultured rat cardiac myocytes and cardiac fibroblasts
Comparison
Triiodothyronine, angiotensin II, Bay-k 8644… vs Untreated control cells
Design
Preclinical
Authors
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Should not change practice in cardiac patients; leaves open a potential Ang II–thyroid hormone interaction in human myocardium.
Do triiodothyronine and angiotensin II increase Type 1 deiodinase activity and mRNA expression in cultured rat cardiac myocytes?
Angiotensin II and triiodothyronine increase Type 1 deiodinase gene expression and activity in cultured rat cardiac myocytes, suggesting a mechanism by which Ang II modulates thyroid hormone action in the heart.
Yonemoto et al. (1999) studied this question.
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