Population
Rat model of right-ventricular (RV) hypertrophy induced by pressure-overload
Comparison
Pressure-overload induced RV hypertrophy vs Non-hypertrophic left ventricle and animals with…
Design
Preclinical
Authors
Loading...
D3 upregulation may worsen local hypothyroidism and RV dysfunction in animals; leaves open therapeutic relevance in human heart failure.
Induction of thyroid hormone-degrading type III deiodinase in hypertrophic and failing ventricles may contribute to a local hypothyroid state, potentially worsening contractile dysfunction.
Wassen et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: