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October 1, 2004The Heart Surgery ForumOpen Access

New Flexible Polymeric Heart Valve Prostheses for the Mitral and Aortic Positions

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Why the study?

Do polycarbonate urethane (PCU) valve prostheses improve durability and hemodynamics compared to commercial bioprostheses in a growing calf model?

Population

Growing calf model

Comparison

Polycarbonate urethane mitral and aortic valve… vs Commercial bioprostheses

Design

Preclinical

Follow-up

20 weeks

Authors

SDSabine DaebritzBFBernd FaustenBHBenita Hermanns

Discussion

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Overview

PCU valves show durability advantage in calves; hypothesis-generating and should not yet change practice.

Structured PICO

Do polycarbonate urethane (PCU) valve prostheses improve durability and hemodynamics compared to commercial bioprostheses in a growing calf model?

P
Population
Growing calf model (n=23 valves total: 14 PCU [7 mitral, 7 aortic] and 9 commercial bioprostheses [7 mitral, 2 aortic])
I
Intervention
Polycarbonate urethane (PCU) mitral and aortic valve prostheses
C
Comparator
Commercial bioprostheses
O
Outcome
In vivo durability, hemodynamics, and survivalsurrogate

New flexible polycarbonate urethane valve prostheses demonstrated superior durability and survival compared to commercial bioprostheses in a 20-week growing calf model.

Cite This Study

Daebritz et al. (2004) studied this question.

synapsesocial.com/papers/6a70d5b45d37378ac1ddfdf5https://doi.org/10.1532/hsf98.20041083
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