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September 9, 2003CirculationOpen Access

Introduction of a Flexible Polymeric Heart Valve Prosthesis With Special Design for Mitral Position

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Why the study?

Does a polycarbonaturethane bileaflet heart valve prosthesis improve hemodynamic performance and durability compared to commercial bioprostheses in the mitral position in growing calves?

Population

14 growing Jersey calves (age 3-5 months, weight 60-97 kg)

Comparison

Polycarbonaturethane bileaflet heart valve… vs Commercial bioprostheses implanted in mitral…

Design

Preclinical

Follow-up

up to 20 weeks

Authors

SDSabine DaebritzBoston UniversityJSJörg S. SachwehUniversität HamburgBHBenita HermannsRWTH Aachen University

Discussion

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Implication

PCU valves merit further development; extends preclinical durability data in calves but leaves open human translation and requires clinical trials.

Structured PICO

Does a polycarbonaturethane bileaflet heart valve prosthesis improve hemodynamic performance and durability compared to commercial bioprostheses in the mitral position in growing calves?

P
Population
14 growing Jersey calves (age 3-5 months, weight 60-97 kg)
I
Intervention
Polycarbonaturethane (PCU) bileaflet heart valve prosthesis with special design for the mitral position (n=7)
C
Comparator
Commercial bioprostheses (Perimount, n=4; Mosaic, n=3) implanted in mitral position (n=7)
O
Outcome
Hemodynamic performance, durability, calcification, and structural changes evaluated by echocardiography and autopsy after up to 20 weekssurrogate

A novel polycarbonaturethane mitral valve prosthesis demonstrated superior in vivo durability and hemodynamic performance with less calcification compared to commercial bioprostheses in a calf model.

Cite This Study

Daebritz et al. (2003) studied this question.

synapsesocial.com/papers/6a9982c82a5b83337dab9fa0https://doi.org/10.1161/01.cir.0000087655.41288.dc
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polyurethane: material for the next generation of heart valve prostheses?2000 · 148 citations
  2. 2Mechanical and morphological study of biostable polyurethane heart valve leaflets explanted from sheep2002 · 53 citations
  3. 3Mitral Replacement1961 · 670 citations
  4. 4Elective Countershock in Unanesthetized Patients with Use of an Esophageal Electrode1966 · 54 citations