January 1, 2012Cardiovascular DiabetologyOpen Access

The metabolic syndrome and progression of carotid atherosclerosis over 13 years. The Tromsø study

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Why the study?

Does metabolic syndrome predict the progression of carotid atherosclerosis over 13 years?

Population

2,974 participants in the population-based Tromsø Study who underwent carotid ultrasound examinations at…

Comparison

Metabolic syndrome defined according to a… vs Participants without metabolic syndrome

Design

Cohort

Follow-up

13 years

Authors

MHMarit HerderUiT The Arctic University of Norway KAKjell Arne ArntzenUniversity Hospital of North Norway SJStein Harald JohnsenUniversity Hospital of North Norway

Discussion

Member takes

Implication

MetS may flag carotid atherosclerosis progression risk in younger men; hypothesis-generating and should not yet change practice.

Structured PICO

Does metabolic syndrome predict the progression of carotid atherosclerosis over 13 years?

Population

2,974 participants (1,442 men and 1,532 women) in the population-based Tromsø Study who underwent carotid ultrasound examinations at baseline (1994-5) and at 13-year follow-up (2007-8). 551 participants (278 men, 273 women) fulfilled criteria for Metabolic Syndrome.

Intervention

Metabolic syndrome (MetS) defined according to a modified version of the National Cholesterol Education Program Adult Treatment Panel III (NCEP, ATPIII)

Comparator

Participants without metabolic syndrome

Outcome

Carotid atherosclerosis assessed as total plaque area (TPA) and mean intima-media thickness (IMT) at follow-up, and as change in IMT and TPA from baseline to follow-upsurrogate

Metabolic syndrome is associated with increased carotid intima-media thickness and total plaque area, and predicts atherosclerotic progression particularly in younger men, suggesting a role in early atherogenesis.

Cite This Study

Herder et al. (2012) studied this question.

synapsesocial.com/papers/6a70db106c240de38cdbf767 https://doi.org/10.1186/1475-2840-11-77

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The metabolic syndrome and progression of carotid atherosclerosis over 13 years. The Tromsø study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The metabolic syndrome and progression of carotid atherosclerosis over 13 years. The Tromsø study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider