Population
Preclinical model (brain infusion into caudate putamen)
Design
Preclinical
Follow-up
up to 48 hours
Authors
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Animal data on xanthine oxidase and edema warrant no practice change; leaves open antioxidant strategies for human cerebral injury.
Oxygen-derived free radicals damage endothelial cells of the blood-brain barrier, leading to brain edema and structural damage of neurons and glia.
Chan et al. (1984) studied this question.
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