Why the study?
Does pretreatment with allopurinol or dimethyl sulfoxide prevent ischemia-induced vascular permeability in a cat ileum model?
Population
Cat ileum model subjected to 1 hour of intestinal ischemia
Comparison
Pretreatment with allopurinol or dimethyl… vs Ischemia without pretreatment
Design
Preclinical
Authors
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Does not support clinical use in intestinal ischemia; leaves open translation of xanthine oxidase or radical scavenging benefits to human models.
Does pretreatment with allopurinol or dimethyl sulfoxide prevent ischemia-induced vascular permeability in a cat ileum model?
In a cat model of intestinal ischemia, inhibition of xanthine oxidase or scavenging of hydroxyl radicals prevents ischemia-induced vascular permeability, highlighting their mechanistic role in vascular injury.
Parks et al. (1983) studied this question.
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