Heritability and intrafamilial aggregation of arterial characteristics
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Population
494 participants from 148 nuclear families recruited from the general population in Cracow, Hechtel-Eksel…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports genetic basis for arterial stiffness; extends family studies but leaves open prospective validation and clinical utility.
Structured PICO
P
Population
494 participants from 148 nuclear families (204 parents, mean age 51.7 years; 290 offspring, mean age 29.4 years) recruited from the general population in Cracow (Poland), Hechtel-Eksel (Belgium), and Pilsen (Czech Republic).
O
Outcome
Heritability and intrafamilial aggregation of indexes of arterial stiffness (peripheral pulse pressure, central pulse pressure, peripheral and central augmentation indexes, aortic pulse wave velocity)surrogate
Significant intrafamilial concordance and heritability of various indexes of arterial stiffness support the presence of shared genetic determinants underlying these traits.
Limitations
- Different devices used to measure aortic PWV
- Relatively small sample size of 494 family members
- Heritability estimates are population-specific
Cite This Study
Seidlerová et al. (2008) studied this question.
Topics
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