What question did this study set out to answer?

Assess long-term trends in febrile respiratory disease and evaluate the impact of targeted vaccination programs among military recruits over a 30-year period.

November 1, 1983The Journal of Infectious Diseases

Viral Respiratory Disease at Lowry Air Force Base in Denver, 1952-1982

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Authors

GMGordon MeiklejohnNational Institutes of Health

Discussion

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Implication

Longitudinal surveillance reveals comprehensive vaccination dramatically reduces febrile respiratory illness in military recruits, highlighting the effectiveness of routine immunization.

Key Points

Assess long-term trends in febrile respiratory disease and evaluate the impact of targeted vaccination programs among military recruits over a 30-year period.
Conducted 30-year laboratory-confirmed epidemiological surveillance (1952–1982) of febrile respiratory illnesses at Lowry Air Force Base.
Evaluated protective efficacy across ten controlled trials of inactivated influenza vaccines and routine recruit administration of live oral adenovirus (types 4 and 7), rubella, and rubeola vaccines.
Vaccination reduced the burden of influenza A to insignificant levels despite virus reintroductions, with failures limited to years with antigenic shift (1968) or major antigenic drift (1972).
Live oral adenovirus types 4 and 7 vaccines virtually eliminated adenovirus disease, while targeted immunization eliminated rubella and rubeola among recruits.
Overall rates of laboratory-confirmed febrile respiratory disease declined substantially across the surveillance timeframe.

Cite This Study

Gordon Meiklejohn (1983) studied this question.

synapsesocial.com/papers/6a70dff587f921057127f3f2 https://doi.org/10.1093/infdis/148.5.775

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November 1, 1983The Journal of Infectious Diseases

Viral Respiratory Disease at Lowry Air Force Base in Denver, 1952-1982

View Full Paper

Ask AI

Bookmark

Authors

GMGordon MeiklejohnNational Institutes of Health

Discussion

Member takes

Implication

Longitudinal surveillance reveals comprehensive vaccination dramatically reduces febrile respiratory illness in military recruits, highlighting the effectiveness of routine immunization.

Key Points

Assess long-term trends in febrile respiratory disease and evaluate the impact of targeted vaccination programs among military recruits over a 30-year period.
Conducted 30-year laboratory-confirmed epidemiological surveillance (1952–1982) of febrile respiratory illnesses at Lowry Air Force Base.
Evaluated protective efficacy across ten controlled trials of inactivated influenza vaccines and routine recruit administration of live oral adenovirus (types 4 and 7), rubella, and rubeola vaccines.
Vaccination reduced the burden of influenza A to insignificant levels despite virus reintroductions, with failures limited to years with antigenic shift (1968) or major antigenic drift (1972).
Live oral adenovirus types 4 and 7 vaccines virtually eliminated adenovirus disease, while targeted immunization eliminated rubella and rubeola among recruits.
Overall rates of laboratory-confirmed febrile respiratory disease declined substantially across the surveillance timeframe.

Cite This Study

Gordon Meiklejohn (1983) studied this question.

synapsesocial.com/papers/6a70dff587f921057127f3f2 https://doi.org/10.1093/infdis/148.5.775

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