January 1, 2004Hypertension ResearchOpen Access

Additive Beneficial Effects of the Combination of a Calcium Channel Blocker and an Angiotensin Blocker on a Hypertensive Rat-Heart Failure Model

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Why the study?

Does the combination of a calcium channel blocker with an ACE inhibitor or ARB improve survival and cardiac remodeling in a rat model of hypertensive heart failure with preserved systolic function?

Population

Dahl salt-sensitive rats fed a high-salt diet from 7 weeks of age, developing hypertension and heart failure…

Comparison

Azelnidipine, temocapril, olmesartan, and their… vs Monotherapy

Design

Preclinical

Authors

SKShokei Kim‐MitsuyamaGeneral / Preventive / Lipids YIYasukatsu IzumiOsaka Metropolitan University YIYasuhiro IzumiyaKumamoto University

Discussion

Member takes

Implication

May support CCB-ACEI combinations in hypertensive HFpEF rat models; leaves open translation to clinical practice.

Structured PICO

Does the combination of a calcium channel blocker with an ACE inhibitor or ARB improve survival and cardiac remodeling in a rat model of hypertensive heart failure with preserved systolic function?

Population

Dahl salt-sensitive rats (DS rats) fed a high-salt diet (8% NaCl) from 7 weeks of age, developing hypertension and heart failure with preserved systolic function

Intervention

Azelnidipine (1 mg/kg/day), temocapril (10 mg/kg/day), olmesartan (5 mg/kg/day), and their combinations

Comparator

Monotherapy (azelnidipine, temocapril, or olmesartan alone)

Outcome

Survival rate, cardiac hypertrophy, cardiac fibrosis, gene expressions (BNP, TGF-beta1, collagen I, collagen III, MCP-1), cardiac diastolic dysfunction, and blood pressuresurrogate

The combination of a calcium channel blocker with an ARB or ACE inhibitor provides additive benefits on survival and cardiac fibrosis in a hypertensive rat model of heart failure with preserved systolic function.

Cite This Study

Kim‐Mitsuyama et al. (2004) studied this question.

synapsesocial.com/papers/6a70e38875498292b70a5fc6 https://doi.org/10.1291/hypres.27.771

Topics

Hypertension management Echocardiography

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Additive Beneficial Effects of the Combination of a Calcium Channel Blocker and an Angiotensin Blocker on a Hypertensive Rat-Heart Failure Model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Additive Beneficial Effects of the Combination of a Calcium Channel Blocker and an Angiotensin Blocker on a Hypertensive Rat-Heart Failure Model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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