June 14, 2012PLoS ONEOpen Access

Calcium Channel Blockers, More than Diuretics, Enhance Vascular Protective Effects of Angiotensin Receptor Blockers in Salt-Loaded Hypertensive Rats

Q: What is the clinical evidence from this study?

Study design: Other. Population: Salt-loaded hypertension (n=48). Intervention: Olmesartan combined with azelnidipine vs. Olmesartan 1 mg/kg/day + hydrochlorothiazide 5 mg/kg/day. Primary outcome: Vascular endothelial function (acetylcholine-induced vascular endothelium-dependent relaxation) (p=<0.01).

View Full Paper

Ask AI

Bookmark

Key result

Azelnidipine enhanced the amelioration of vascular endothelial dysfunction and remodeling by olmesartan to a greater extent than did hydrochlorothiazide in salt-loaded hypertensive rats (P<0.01).

Why the study?

Does the combination of an ARB and a CCB improve vascular protection more than an ARB and a diuretic in salt-loaded hypertensive rats?

Population

11-week-old male stroke-prone spontaneously hypertensive rats fed a diet containing 8% sodium, and control…

Comparison

Olmesartan combined with azelnidipine… vs Olmesartan combined with hydrochlorothiazide…

Design

Preclinical, randomly assigned to 6 groups, counted in 4 horizontal LV in a…

Follow-up

4 weeks

Authors

EYEiichiro YamamotoSapporo Medical University KKKeiichiro KataokaKumamoto University YDYi‐Fei DongNanchang University

Discussion

Member takes

Implication

Should not yet change antihypertensive regimens in practice; leaves open whether ARB-CCB combinations confer superior vascular protection in humans.

Structured PICO

Does the combination of an ARB and a CCB improve vascular protection more than an ARB and a diuretic in salt-loaded hypertensive rats?

Population

48 male stroke-prone spontaneously hypertensive rats and control Wistar-Kyoto rats, fed an 8% sodium diet, treated for 4 weeks to evaluate vascular protection.

Intervention

Olmesartan (1 mg/kg/day) combined with azelnidipine (1 mg/kg/day) administered orally by gastric gavage once a day for 4 weeks.

Comparator

Olmesartan (1 mg/kg/day) combined with hydrochlorothiazide (5 mg/kg/day) administered orally by gastric gavage once a day for 4 weeks.

Outcome

Vascular endothelial dysfunction and remodeling (measured by acetylcholine-induced vascular endothelium-dependent relaxation, vascular NADPH oxidase activity, superoxide levels, and eNOS/Akt pathway activation).surrogate

Main Result

p-value: p=<0.01

In salt-loaded hypertensive rats, combining an ARB with a CCB provides greater vascular protection than combining an ARB with a diuretic, despite similar blood pressure reductions.

Limitations

Extrapolation of experimental findings from animal models to clinical situations should be made with caution.
Extrapolation of experimental findings to clinical settings requires caution

Cite This Study

Yamamoto et al. (2012) studied Salt-loaded hypertension (n=48). Olmesartan combined with azelnidipine vs. Olmesartan 1 mg/kg/day + hydrochlorothiazide 5 mg/kg/day was evaluated on Vascular endothelial function (acetylcholine-induced vascular endothelium-dependent relaxation) (p=<0.01). Azelnidipine enhanced the amelioration of vascular endothelial dysfunction and remodeling by olmesartan to a greater extent than did hydrochlorothiazide in salt-loaded hypertensive rats (P<0.01).

synapsesocial.com/papers/6a8c2b69de5ec4e001e3ede1 https://doi.org/10.1371/journal.pone.0039162

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

June 14, 2012PLoS ONEOpen Access

Calcium Channel Blockers, More than Diuretics, Enhance Vascular Protective Effects of Angiotensin Receptor Blockers in Salt-Loaded Hypertensive Rats

View Full Paper

Ask AI

Bookmark

Key result

Azelnidipine enhanced the amelioration of vascular endothelial dysfunction and remodeling by olmesartan to a greater extent than did hydrochlorothiazide in salt-loaded hypertensive rats (P<0.01).

Why the study?

Does the combination of an ARB and a CCB improve vascular protection more than an ARB and a diuretic in salt-loaded hypertensive rats?

Population

11-week-old male stroke-prone spontaneously hypertensive rats fed a diet containing 8% sodium, and control…

Comparison

Olmesartan combined with azelnidipine… vs Olmesartan combined with hydrochlorothiazide…

Design

Preclinical, randomly assigned to 6 groups, counted in 4 horizontal LV in a…

Follow-up

4 weeks

Authors

EYEiichiro YamamotoSapporo Medical University KKKeiichiro KataokaKumamoto University YDYi‐Fei DongNanchang University

Discussion

Member takes

Implication

Should not yet change antihypertensive regimens in practice; leaves open whether ARB-CCB combinations confer superior vascular protection in humans.

Structured PICO

Does the combination of an ARB and a CCB improve vascular protection more than an ARB and a diuretic in salt-loaded hypertensive rats?

Population

48 male stroke-prone spontaneously hypertensive rats and control Wistar-Kyoto rats, fed an 8% sodium diet, treated for 4 weeks to evaluate vascular protection.

Intervention

Olmesartan (1 mg/kg/day) combined with azelnidipine (1 mg/kg/day) administered orally by gastric gavage once a day for 4 weeks.

Comparator

Olmesartan (1 mg/kg/day) combined with hydrochlorothiazide (5 mg/kg/day) administered orally by gastric gavage once a day for 4 weeks.

Outcome

Main Result

p-value: p=<0.01

In salt-loaded hypertensive rats, combining an ARB with a CCB provides greater vascular protection than combining an ARB with a diuretic, despite similar blood pressure reductions.

Limitations

Extrapolation of experimental findings from animal models to clinical situations should be made with caution.
Extrapolation of experimental findings to clinical settings requires caution

Cite This Study

synapsesocial.com/papers/6a8c2b69de5ec4e001e3ede1 https://doi.org/10.1371/journal.pone.0039162

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark