What question did this study set out to answer?

To identify and characterize the specific phospholipid molecular species present in canine myocardial sarcoplasmic reticulum compared to skeletal muscle.

March 1, 1985Biochemistry

Identification of plasmalogen as the major phospholipid constituent of cardiac sarcoplasmic reticulum

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Authors

RGRichard W. GrossGeneral / Preventive / Lipids

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Implication

Hypothesis-generating SR lipid profile in canine myocardium; leaves open functional roles in human cardiac membranes.

Key Points

To identify and characterize the specific phospholipid molecular species present in canine myocardial sarcoplasmic reticulum compared to skeletal muscle.
Analyzed phospholipid species from canine myocardial and skeletal muscle sarcoplasmic reticulum using fast atom bombardment mass spectrometry and reverse-phase high-performance liquid chromatography.
Cardiac sarcoplasmic reticulum contains 1.4 µmol of lipid Pi/mg of protein, comprising 53% plasmalogen overall and 73% plasmalogen in the ethanolamine glycerophospholipid fraction.
Canine skeletal muscle sarcoplasmic reticulum contains only 19% total plasmalogen, although ethanolamine plasmalogen constitutes 78% of its ethanolamine glycerophospholipid pool.
Cardiac ethanolamine plasmalogen predominantly features 18-carbon vinyl ethers at the sn-1 position and arachidonic acid at the sn-2 position.

Cite This Study

Richard W. Gross (1985) studied this question.

synapsesocial.com/papers/6a70e578f44fa9f079dea3ec https://doi.org/10.1021/bi00328a014

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Identification of plasmalogen as the major phospholipid constituent of cardiac sarcoplasmic reticulum

Discussion

Member takes

Implication

Key Points

Cite This Study

Identification of plasmalogen as the major phospholipid constituent of cardiac sarcoplasmic reticulum

Discussion

Member takes

Implication

Key Points

Cite This Study

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