Population
Cultured human umbilical vein and coronary artery endothelial cells
Comparison
Addition of exogenous big ET-1 and stimulation… vs Nonpermeabilized cells
Design
Preclinical
Authors
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Suggests regulated endothelin-1 release from endothelial granules; leaves open translation to human vascular disease or therapy.
Endothelin-converting enzymes are located within endothelial storage granules (Weibel-Palade bodies), where they process big ET-1 to mature endothelin-1 for regulated release.
Russell et al. (1998) studied this question.
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