Population
Recombinant Chinese hamster ovary luciferase reporter cell line permanently expressing the human ET…
Design
Preclinical
Authors
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Animal data indicate ECE-1a has intracellular activity; leaves open whether membrane-permeable inhibitors are needed for endothelin blockade.
ECE-1a exhibits both intracellular and extracellular activity, indicating that effective ECE-1a inhibitors must be able to cross plasma and vesicle membranes.
Parnot et al. (1997) studied this question.
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