Why the study?
Dysfunctional perivascular adipose tissue secretes pro-inflammatory cytokines and adipokines that contribute to cardiovascular disease pathogenesis.
Key points are not available for this paper at this time.
Design
Review
Suggests PVAT as a therapeutic target in atherosclerosis; leaves open the need for clinical validation of interventions.
Perivascular adipose tissue (PVAT) is an active regulator of vascular homeostasis. In physiological conditions, it maintains normal function of vessels, releasing antiatherogenic, anti-inflammatory and vasodilating biologically active substances. Dysfunctional PVAT secretes pro-inflammatory cytokines and adipokines, which play an important role in the development of cardiovascular diseases. This review considers the PVAT function in health and disease, its contribution to the pathogenesis of atherosclerosis, hypertension, aortic aneurysm and vasculitis. In addition, novel methods of non-invasive PVAT assessment and potential strategies for targeted treatment of cardiovascular diseases are presented.
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Kim et al. (2021) studied this question.
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