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March 6, 2004European Journal of Heart FailureOpen Access

Desmin-Free Cardiomyocytes and Myocardial Dysfunction in End Stage Heart Failure

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Why the study?

Does desmin content in myocardial tissue correlate with cardiac function in patients with end-stage heart failure of ischaemic origin?

Population

18 explanted hearts from patients transplanted for end-stage heart failure due to ischaemic cardiomyopathy…

Design

Case-control

Authors

SSSalvatore Di SommaHeart Failure & TransplantMBM.P. Di BenedettoGSGiuliana SalvatoreParthenope University of Naples

Discussion

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Implication

Desmin loss should not yet change management in end-stage ICM; leaves open its role as biomarker or therapeutic target.

Structured PICO

Does desmin content in myocardial tissue correlate with cardiac function in patients with end-stage heart failure of ischaemic origin?

P
Population
18 explanted hearts from patients transplanted for end-stage heart failure due to ischaemic cardiomyopathy (ICM) and 12 control myocardial tissues (6 women with breast cancer prior to chemotherapy, 4 male donors for heart transplantation, 2 autoptic hearts from non-cardiac deaths).
C
Comparator
Control myocardial tissue from individuals without ischaemic cardiomyopathy
O
Outcome
Desmin content in myocardial tissue and its correlation with cardiac function (ejection fraction and capillary wedge pressure)surrogate

End-stage ischaemic heart failure is associated with a significant reduction in myocardial desmin content, which correlates with reduced cardiac function.

Cite This Study

Somma et al. (2004) studied this question.

synapsesocial.com/papers/6a70f10e31a3df8243292ebchttps://doi.org/10.1016/j.ejheart.2003.07.010

Topics

Heart transplantationHFrEF treatmentHeart failure
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  1. 1Ischaemia and the myocyte cytoskeleton: review and speculation1993 · 140 citations
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