Why the study?
The ideal achieved blood pressure in end-stage renal disease patients with coronary artery disease after coronary intervention was unclear.
Does achieving a systolic BP of 140-149 mm Hg and diastolic BP of 80-89 mm Hg reduce cardiovascular events in ESRD patients following PCI?
Does achieving a systolic BP of 140-149 mm Hg and diastolic BP of 80-89 mm Hg reduce cardiovascular events in ESRD patients following PCI?
In ESRD patients undergoing PCI, achieved blood pressures of 140-149/80-89 mm Hg are associated with the lowest risk of cardiovascular events, demonstrating a J-shaped relationship.
) still unclear. The authors aimed to investigate the ideal achieved BP in ESRD patients with CAD after coronary intervention. Five hundred and seventy-five ESRD patients who had undergone percutaneous coronary interventions (PCIs) were enrolled and their clinical outcomes were analyzed according to the category of systolic BP (SBP) and diastolic BP (DBP) achieved. The clinical outcomes included major cardiovascular events (MACE) and MACE plus hospitalization for congestive heart failure (total cardiovascular (CV) event).The mean systolic BP was 135.0 ± 24.7 mm Hg and the mean diastolic BP was 70.7 ± 13.1 mm Hg. Systolic BP 140-149 mm Hg and diastolic BP 80-89 mm Hg had the lowest MACE (11.0%; 13.2%) and total CV event (23.3%; 21.1%). Patients with systolic BP < 120 mm Hg had a higher risk of MACE (HR: 2.01; 95% CI: 1.17-3.46, p = .008) than those with systolic BP 140-149 mm Hg. Patients with systolic BP ≥ 160 mm Hg (HR: 1.84; 95% CI, 3.27-1.04, p = .04) and diastolic blood BP ≥ 90 mm Hg (HR: 2.19; 95% CI: 1.15-4.16, p = .02) had a higher risk of total CV event rate when compared to those with systolic BP 140-149 mm Hg and diastolic BP 80-89 mm Hg. A J-shaped association between systolic (140-149 mm Hg) and diastolic (80-89 mm Hg) BP and decreased cardiovascular events for CAD was found in patients with ESRD after undergoing PCI in non-Western population.
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Yang et al. (2021) studied this question.
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