March 1, 1988Journal of Biological ChemistryOpen Access

Different secretory pathways of renin from mouse cells transfected with the human renin gene.

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Structured PICO

Population

Mammalian cells in culture (mouse L929 fibroblasts, Chinese hamster ovary cells, and mouse AtT-20 pituitary tumor cells)

Intervention

Transfection with the human renin gene and a selectable plasmid (pSV2Neo), and stimulation with 8-bromo-cAMP

Outcome

Synthesis and secretion pathways of prorenin and mature active reninsurrogate

This study demonstrates that human renin can be secreted via two distinct cellular pathways: a constitutive pathway for prorenin and a regulated pathway for mature renin.

Discussion

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Implication

Cell models reveal distinct renin secretion pathways; leaves open relevance to human cardiovascular regulation.

Cite This Study

Pratt et al. (1988) studied this question.

synapsesocial.com/papers/6a70f23b8031ec7bb1dcadd8 https://doi.org/10.1016/s0021-9258(18)69046-5

View Full Paper

Ask AI

Bookmark

Different secretory pathways of renin from mouse cells transfected with the human renin gene.

Structured PICO

Discussion

Implication

Cite This Study

Different secretory pathways of renin from mouse cells transfected with the human renin gene.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider