Population
Recombinant Chinese hamster ovary cells stably transfected with wild type or mutated human kidney C receptors
Comparison
Mutations in the C receptor or hypertonic sucrose vs Wild type human kidney C receptors
Design
Preclinical
Authors
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Tyr508 and the cytoplasmic domain are key for NPR-C clearance in vitro; leaves open relevance to in vivo natriuretic peptide regulation or therapy.
The cytoplasmic domain of C receptors, specifically Tyr508, and constitutive receptor dimerization are major molecular determinants of the clearance function of natriuretic peptide C receptors.
Cohen et al. (1996) studied this question.
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