What question did this study set out to answer?

The study aims to investigate factors influencing persistence with antihypertensive drugs in daily practice.

September 22, 2005Pharmacoepidemiology and Drug SafetyOpen Access

Differences in antihypertensive drug persistence associated with drug class and gender: a PHARMO study

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Why the study?

Do different antihypertensive drug classes and gender affect one-year treatment persistence in patients newly receiving antihypertensive therapy?

Population

Patients who newly received antihypertensive therapy between 1997 and 2001 in the Netherlands.

Comparison

Antihypertensive drug classes vs Comparison between different antihypertensive…

Design

Cohort

Follow-up

1 year

Authors

JEJoëlle A. ErkensPharmo Institute MPMartien M. J. PannemanPharmo Institute OKOlaf H. KlungelGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Lower persistence with diuretics and in women may require targeted monitoring; leaves open effects on outcomes and need for adherence trials.

Key Points

The study aims to investigate factors influencing persistence with antihypertensive drugs in daily practice.
Data from the PHARMO database (n=950,000) was used, focusing on 17,113 newly treated antihypertensive users.
A sample of 500 patients per drug class was selected for analysis of one-year persistence rates.
Kaplan-Meier curves were utilized to assess persistence adjusted for factors like age and comorbidities.
Persistence was highest for angiotensin II receptor blockers (62.0%) and lowest for diuretics (33.0%).
Women demonstrated lower persistence (40.1%) compared to men (50.2%), with an odds ratio of 0.7 [95%CI: 0.6-0.8].
The persistence differences between drug classes were more pronounced in women than in men.

Structured PICO

Do different antihypertensive drug classes and gender affect one-year treatment persistence in patients newly receiving antihypertensive therapy?

Population

Patients who newly received antihypertensive (AHT) therapy between 1997 and 2001 in the Netherlands (random samples of 500 patients per drug class drawn from 17,113 eligible patients).

Intervention

Antihypertensive drug classes (angiotensin II receptor blockers [ARBs], angiotensin converting enzyme inhibitors [ACE-inhibitors], betablockers, calcium channel blockers, and diuretics)

Comparator

Comparison between different antihypertensive drug classes and between genders

Outcome

One-year persistence (defined as the percentage of patients using AHTs at least 270 days and receiving AHT in 3 months after the 1-year follow-up period, and Catalan method)

Antihypertensive treatment persistence varies significantly by drug class, being highest with ARBs and lowest with diuretics, and is notably lower in women than in men.

Cite This Study

Erkens et al. (2005) studied this question.

synapsesocial.com/papers/6a70f35631a3df8243293298 https://doi.org/10.1002/pds.1156

Topics

Hypertension management

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Implication

Lower persistence with diuretics and in women may require targeted monitoring; leaves open effects on outcomes and need for adherence trials.

Differences in antihypertensive drug persistence associated with drug class and gender: a PHARMO study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Differences in antihypertensive drug persistence associated with drug class and gender: a PHARMO study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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