Key result
Initial antihypertensive monotherapy with ARBs was associated with higher persistence (51.9% vs 29.9%) and lower discontinuation (HR 0.593, P<.0001) compared with diuretics over 1 year.
Why the study?
Does initial antihypertensive drug class affect treatment regimen persistence and compliance in newly treated patients?
Cohort (n=242,882)
Does initial antihypertensive drug class affect treatment regimen persistence and compliance in newly treated patients?
Hazard Ratio: 0.593
Absolute Event Rate: 51.9% vs 29.9%
p-value: p=<.0001
Patients initiated on ARBs or ACEIs demonstrate higher medication persistence and compliance compared to those started on diuretics, beta-blockers, or calcium channel blockers.
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May favor initial ARBs for persistence in observational cohorts; leaves open whether randomized trials would confirm class effects on adherence.
Patel et al. (2007) conducted a cohort in Hypertension (n=242,882). Angiotensin II receptor blockers (ARBs) vs. Diuretics was evaluated on Treatment persistence and discontinuation (HR 0.593, p=<.0001). Initial antihypertensive monotherapy with ARBs was associated with higher persistence (51.9% vs 29.9%) and lower discontinuation (HR 0.593, P<.0001) compared with diuretics over 1 year.
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