Why the study?
Aortic dissection is an adverse event of angiogenesis inhibitors, but the association between these drugs and aortic dissection remains unclear.
Do angiogenesis inhibitors increase the risk of developing aortic dissection?
Population
LAB mice, cultured endothelial cells, and real-world database cohorts
Comparison
Angiogenesis inhibitors vs other hypertension-inducing drugs or control
Design
Integrated translational study combining disproportionality analysis, retrospective cohort analysis, and in vivo/in vitro experiments
Authors
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Observational data on angiogenesis inhibitors and aortic dissection risk should not change practice; leaves open need for prospective confirmation.
Do angiogenesis inhibitors increase the risk of developing aortic dissection?
Angiogenesis inhibitors increase the risk of aortic dissection through drug-specific hypertension mediated by endothelial cell damage and endothelin-1 expression.
Tsujinaka et al. (2023) studied this question.
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