Why the study?
Does isolated atrial systole without subsequent ventricular systole cause mitral valve reflux in an experimental model of acute heart block?
Population
Preclinical model undergoing stellate ganglionectomy, vagotomy, and acute heart block
Comparison
Isolated atrial systoles vs Normally sequenced ventricular systoles…
Design
Preclinical
Authors
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May indicate diastolic mitral incompetence in heart block; hypothesis-generating in animal model, needs human validation.
Does isolated atrial systole without subsequent ventricular systole cause mitral valve reflux in an experimental model of acute heart block?
Isolated atrial systoles not followed by ventricular systoles fail to effectively close the mitral valve, leading to diastolic mitral incompetence.
Williams et al. (1968) studied this question.
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