Why the study?
Does the heparin sensitivity of different lots of APTT reagents from the same manufacturer vary significantly?
Population
Different lots of activated partial thromboplastin time reagents produced by three major North American…
Follow-up
8 years
Authors
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May warrant lot-specific APTT calibration in labs to avoid dosing variability; leaves open standardization needs for heparin monitoring.
Does the heparin sensitivity of different lots of APTT reagents from the same manufacturer vary significantly?
Significant lot-to-lot variation in heparin sensitivity of APTT reagents from the same manufacturer can lead to inconsistent heparin dosing if standard ratios are used.
Shojania et al. (1988) studied this question.
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