Population
Carrier women of factor-V Leiden mutation and their offspring, and individuals with thrombophilic disorders
Design
Review
Authors
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Alerts clinicians to counseling needs in carriers; leaves open whether screening improves offspring outcomes.
Factor-V Leiden and other thrombophilic disorders are recognized risk factors for cerebral palsy and pregnancy complications, with wide clinical implications for carrier women and their offspring.
Harum et al. (1999) studied this question.
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