Why the study?
Does valvular surgery alter insulin sensitivity and systemic glucose uptake in patients with valvular aortic stenosis?
Does valvular surgery alter insulin sensitivity and systemic glucose uptake in patients with valvular aortic stenosis?
Patients with valvular aortic stenosis exhibit a preoperative metabolic adaptation with increased insulin sensitivity, which is acutely reversed following valvular surgery.
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Reversal of heightened preoperative insulin sensitivity after valvular surgery may affect perioperative glucose management; hypothesis-generating for long-term outcomes.
The dose-response relationship between plasma insulin and systemic glucose uptake was studied before, one hour after and 6 months after valvular surgery in 11 patients with valvular aortic stenosis. The immediate effect of valvular surgery was a dramatic rightward shift of the dose-response curve and a decrease in glucose uptake at peak insulin activity. From a comparison between the preoperative and the 6-month postoperative dose-response curves it is concluded that the patients had adapted metabolically to the preoperative haemodynamic situation with increased insulin sensitivity.
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Ekroth et al. (1982) studied this question.
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