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January 1, 1974British journal of surgery

Glucose utilization and insulin secretion during surgery in man

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Why the study?

How does surgery affect glucose utilization and insulin secretion in patients?

Population

18 patients undergoing surgery

Comparison

Intravenous glucose tolerance tests performed… vs Pre-surgery baseline

Design

Cohort

Follow-up

During and after surgery

Authors

PWPeter WrightOxford Brookes UniversityKHK. S. HendersonUniversity of Wisconsin–MadisonIJIvan D A JohnstonQueen's University Belfast

Discussion

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Implication

May promote postoperative catabolism; leaves open whether modulating insulin secretion improves recovery in prospective trials.

Structured PICO

How does surgery affect glucose utilization and insulin secretion in patients?

P
Population
18 patients undergoing surgery
I
Intervention
Intravenous glucose tolerance tests performed before, during, and after surgery
C
Comparator
Pre-surgery baseline
O
Outcome
Glucose utilization and insulin secretionsurrogate

Surgery induces a suppression of insulin secretion and depression of glucose utilization, which may initiate cellular catabolism and urinary nitrogen loss.

Cite This Study

Wright et al. (1974) studied this question.

synapsesocial.com/papers/6a701bdaa528af2d65c35476https://doi.org/10.1002/bjs.1800610103
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serum Insulin and Growth Hormone Response to Hemorrhagic Shock11971 · 31 citations
  2. 2STUDIES OF THE ABSORPTION AND METABOLISM OF GLUCOSE FOLLOWING INJURY1955 · 104 citations