Why the study?
Does dipyridamole terminate or prevent sustained left ventricular tachycardia in patients?
Does dipyridamole terminate or prevent sustained left ventricular tachycardia in patients?
Dipyridamole can terminate and prevent sustained left ventricular tachycardia, suggesting a mechanism involving cyclic AMP-mediated triggered activity.
May support targeted use in refractory VT; hypothesis-generating from case reports only and should not change practice.
Sustained VT in two patients was terminated by intravenous administration of dipyridamole, an adenosine transport inhibitor. VT was induced by rapid atrial or ventricular pacing, isoproterenol, or dibutyryl cyclic AMP infusion, or exercise. VT also was aborted by adenosine triphosphate or acetylcholine injection, or by vagal stimulation. VT was terminated or prevented by verapamil or propranolol. In addition, arrhythmias were prevented by oral administration of dipyridamole. These results suggest that VT is due to cyclic AMP-mediated triggered activity and that inhibition by dipyridamole may be due to a reduction in the intracellular concentration of cyclic AMP.
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Kobayashi et al. (1994) studied this question.