Why the study?
Does high-dose lisinopril improve systolic blood pressure variability compared to low-dose lisinopril in patients with heart failure?
Population
Patients with symptomatic heart failure, left ventricular ejection fraction ≤ 30%, and 2 months of…
Comparison
Lisinopril 35 mg ('high' dose) vs Lisinopril 5 mg ('low' dose)
Design
RCT, randomized
Follow-up
4 weeks
Authors
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High-dose lisinopril increases 24-h SBP variability in HF; challenges higher-dose ACEI strategies and requires outcome validation.
Does high-dose lisinopril improve systolic blood pressure variability compared to low-dose lisinopril in patients with heart failure?
High-dose lisinopril increases circadian systolic blood pressure variability in heart failure patients compared to low-dose therapy.
Giles et al. (2001) studied this question.
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