What question did this study set out to answer?

To evaluate the feasibility and hemodynamic performance of a novel rate-responsive pacemaker that utilizes the QT interval to adjust pacing rate according to metabolic demand.

February 26, 1983BMJOpen Access

Initial experience with a physiological, rate responsive pacemaker.

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Why the study?

Does physiological rate responsive pacing using the QT interval improve cardiac output and exercise capacity compared to fixed rate pacing in patients?

Population

5 patients

Comparison

Physiological rate responsive pacing using the… vs Fixed rate pacing

Design

Case_series

Authors

RDRobert M. DonaldsonBoston University KFK. FoxNorthumbria University ARA F RickardsUniversity College Hospital at Westmoreland Street

Discussion

Member takes

Implication

May improve exercise capacity in select patients; leaves open whether QT-based rate-responsive pacing warrants broader evaluation.

Key Points

To evaluate the feasibility and hemodynamic performance of a novel rate-responsive pacemaker that utilizes the QT interval to adjust pacing rate according to metabolic demand.
Evaluated a novel physiological rate-responsive pacemaker system in five patients (N=5).
Compared hemodynamic and functional performance during exercise between QT-driven rate-responsive pacing and conventional fixed-rate pacing at 70 beats/min.
Exercise induced a smooth, progressive heart rate increase that gradually returned to the baseline pacing rate after physical activity stopped.
Physiological rate-responsive pacing produced a 45% increase in cardiac output relative to fixed-rate pacing.
Maximal exercise capacity increased by 57% with rate-responsive pacing compared to conventional fixed-rate pacing at 70 beats/min.

Structured PICO

Does physiological rate responsive pacing using the QT interval improve cardiac output and exercise capacity compared to fixed rate pacing in patients?

Population

5 patients

Intervention

Physiological rate responsive pacing using the QT interval

Comparator

Fixed rate pacing (conventional pacing at 70 beats/min)

Outcome

Cardiac output and maximal exercise capacitysurrogate

Physiological rate responsive pacing using the QT interval provides a simple means of increasing heart rate and significantly improves cardiac output and exercise capacity compared to fixed rate pacing.

Cite This Study

Donaldson et al. (1983) studied this question.

synapsesocial.com/papers/6a7100ad6c240de38cdc02e2 https://doi.org/10.1136/bmj.286.6366.667

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Initial experience with a physiological, rate responsive pacemaker.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Initial experience with a physiological, rate responsive pacemaker.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider