Key result
Physiologic rate-responsive pacing using the evoked QT principle resulted in significant improvement in exercise tolerance and a 40% increase in cardiac output compared to fixed-rate pacing.
Why the study?
Does rate-responsive pacing using the evoked QT principle improve exercise tolerance and cardiac output compared to fixed-rate pacing in patients requiring pacemakers?
Population
15 patients implanted with a rate-responsive pacemaker using the evoked QT principle
Comparison
Rate-responsive pacing using the evoked QT… vs Fixed-rate pacing (evaluated in 8 patients)
Design
Case_series
Authors
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Should not yet change practice; hypothesis-generating for evoked QT rate-responsive pacing pending controlled trials.
Observational (n=15)
Does rate-responsive pacing using the evoked QT principle improve exercise tolerance and cardiac output compared to fixed-rate pacing in patients requiring pacemakers?
Effect estimate: 40% increase in cardiac output
Rate-responsive pacing using the evoked QT principle provides a physiological response to exercise, significantly improving exercise tolerance and cardiac output compared to fixed-rate pacing.
Donaldson et al. (1983) conducted an observational in Patients requiring pacemakers (n=15). Rate-responsive pacemaker using the evoked QT principle vs. Fixed-rate pacing was evaluated on Cardiac output and exercise tolerance (40% increase in cardiac output). Physiologic rate-responsive pacing using the evoked QT principle resulted in significant improvement in exercise tolerance and a 40% increase in cardiac output compared to fixed-rate pacing.
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