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March 26, 2009American Journal of TransplantationOpen Access

The change in VO2peak (3.11 mL/kg/min, 95% CI: 1.2-5.0 mL/kg/min) was significantly higher after SET versus NT.

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Why the study?

Does 12 weeks of supervised aerobic and strength training improve peak aerobic power, skeletal muscle function, and cardiovascular function in clinically stable heart transplant recipients?

Population

43 clinically stable heart transplant recipients. SET group: n=22, age 57 +/- 10 years, time posttransplant…

Comparison

12 weeks of supervised aerobic and strength… vs No-training (NT) for 12 weeks

Design

RCT, Randomly assigned

Follow-up

12 weeks

Authors

MHMark J. HaykowskyHeart Failure / CardiomyopathyDTDylan TaylorUniversity of AucklandDKD. KimZen-Noh (Japan)

Discussion

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Overview

Supports supervised aerobic and strength training in stable heart transplant recipients; extends RCT evidence for functional gains without LV or endothelial changes.

Structured PICO

Does 12 weeks of supervised aerobic and strength training improve peak aerobic power, skeletal muscle function, and cardiovascular function in clinically stable heart transplant recipients?

P
Population
43 clinically stable heart transplant recipients (HTR). SET group: n=22, age 57 +/- 10 years, time posttransplant 5.4 +/- 4.9 years. NT group: n=21, age 59 +/- 11 years, time posttransplant 4.4 +/- 3.3 years.
I
Intervention
12 weeks of supervised aerobic and strength training (SET)
C
Comparator
No-training (NT) for 12 weeks
O
Outcome
Peak aerobic power (VO2peak), submaximal exercise left ventricular (LV) systolic function, peripheral vascular function, lean tissue mass and maximal strengthsurrogate

A 12-week supervised aerobic and strength training program significantly improves aerobic capacity, lean tissue mass, and muscle strength in clinically stable heart transplant recipients, without altering LV systolic or endothelial function.

Cite This Study

Haykowsky et al. (2009) studied this question.

synapsesocial.com/papers/6a7100e9f44fa9f079dec3cchttps://doi.org/10.1111/j.1600-6143.2008.02531.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deficient acceleration of left ventricular relaxation during exercise after heart transplantation.1992 · 107 citations
  2. 2Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery2002 · 4,614 citations
  3. 3Effect of Sympathetic Reinnervation on Cardiac Performance after Heart Transplantation2001 · 290 citations