Population
Isolated perfused atria prepared from rats
Comparison
Distention of the vein-atrial junction with an… vs Appendectomized atria; absence of BQ-123
Design
Preclinical
Authors
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Does not support clinical translation; leaves open ETA-dependent remote ANF regulation in experimental atrial distention.
Distention of the vein-atrial junction causes remote release of ANF from the atrial appendage via a mechanism involving ETA receptors but not direct ET-1 release.
Deng et al. (1999) studied this question.
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