Key result
Bilateral atrial appendectomy in rats markedly blunted the release of atrial natriuretic factor in response to acute volume expansion (+67% vs +357% in controls, P<0.01).
Why the study?
Does bilateral atrial appendectomy in rats alter the release of atrial natriuretic factor in response to acute stimuli?
Does bilateral atrial appendectomy in rats alter the release of atrial natriuretic factor in response to acute stimuli?
Absolute Event Rate: 67% vs 357%
p-value: p=<.01
Bilateral atrial appendectomy in rats blunts ANF release to volume expansion but not to acute salt load, indicating ANF stores are not significantly depleted.
Preclinical rat data should not guide human care; leaves open appendage contributions to ANF in clinical volume regulation.
The release of atrial natriuretic factor (ANF) after various acute stimuli was studied in conscious chronic bilaterally atrial appendectomized (APP) rats. The response to acute volume expansion was markedly blunted (+67% v +357% in controls, P less than .01). However, the response to norepinephrine infusion was only moderately reduced (+107% v +212%, P less than .05) and the response to acute salt load was identical to that in normal controls (+148% v +180%, P = NS). These results demonstrate that APP rats can increase the secretion of ANF, at least to some acute stimuli. This indicates that the stores of ANF available for release are not significantly depleted after atrial appendectomy.
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Hoffman et al. (1990) studied Bilateral atrial appendectomy (animal model). Bilateral atrial appendectomy vs. Normal controls was evaluated on Release of atrial natriuretic factor (ANF) in response to acute volume expansion (p=<.01). Bilateral atrial appendectomy in rats markedly blunted the release of atrial natriuretic factor in response to acute volume expansion (+67% vs +357% in controls, P<0.01).
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