Time course of release of atrial natriuretic peptide in the anaesthetized dog

View Full Paper

Ask AI

Bookmark

Population

12 chloralose anaesthetized dogs

Comparison

Atrial distension vs Baseline (prior to distension)

Design

Preclinical

Authors

Discussion

Direct atrial stretch triggers ANP release independent of neural reflexes; confirms mechanism in this model but leaves open human translation.

Population

12 chloralose anaesthetized dogs

Intervention

Atrial distension (increasing left atrial pressure by 10 cm H2O during partial mitral obstruction)

Comparator

Baseline (prior to distension)

Outcome

Plasma concentration of immunoreactive atrial natriuretic peptide (IR-ANP) and its time coursesurrogate

Atrial natriuretic peptide is released directly in response to atrial wall stretch rather than via neural or humoral reflex mechanisms.

Ledsome et al. (1986) studied this question.

View Full Paper

Ask AI

Bookmark

Direct atrial stretch triggers ANP release independent of neural reflexes; confirms mechanism in this model but leaves open human translation.