Key result
Increasing the atrial driving rate to 200 beats/min significantly increased atrial natriuretic peptide release from the isolated dog right atrium (2250±130 pg/ml vs 1630±160 pg/ml at 100 beats/min).
Why the study?
Does increased atrial rate stimulate the release of atrial natriuretic peptide in isolated dog right atria?
Does increased atrial rate stimulate the release of atrial natriuretic peptide in isolated dog right atria?
Absolute Event Rate: 2250% vs 1630%
This preclinical study demonstrates that atrial natriuretic peptide is exclusively secreted from the atrium and its release is directly stimulated by an increased atrial rate.
Increased atrial rate may stimulate ANP release in isolated canine atria; leaves open translation to human tachyarrhythmias.
Release of atrial natriuretic peptide (ANP) was investigated using the isolated right atrium (RA) cross-circulated with heparinized arterial blood of the donor dog. ANP concentration of the blood was measured by radioimmunoassay. The plasma ANP concentration of the arterial blood of the donor dog (ANP-D) which perfused the RA preparation was 111 ±18 pg/ml (n=4), while the ANP concentration of venous blood leaving the RA preparation (ANP-A) was 1 680±220 pg/ml (n=4). In comparison, the plasma ANP concentration of venous blood leaving the isolated papillary muscle of the right ventricle (ANP-V) was 106±19 pg/ml (n=4), which was not significantly different from the ANP-D concentration. When the right atrium was electrically driven at a rate of 100 beats/min, almost the same rate as the spontaneous sinoatrial rate of 98±6 beats/min (n=4), the ANP-A concentration was not changed (1630±160 pg/ml, n=4). When the driving rate was increased to 200 beats/min, the ANP-A concentration was significantly increased to 2250±130 pg/ml (n=4). These results suggest that ANP is exclusively secreted from the atrium, but not from the ventricle, and that release of ANP is directly related to atrial rate.
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Motomura et al. (1988) studied this question. Electrical pacing at 200 beats/min vs. Electrical pacing at 100 beats/min was evaluated on ANP concentration of venous blood leaving the RA preparation (pg/ml). Increasing the atrial driving rate to 200 beats/min significantly increased atrial natriuretic peptide release from the isolated dog right atrium (2250±130 pg/ml vs 1630±160 pg/ml at 100 beats/min).
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