Key result
Elevated left atrial pressure stimulates ANP release and depletes atrial ANP granules.
Why the study?
The relationship between left atrial pressure and ANP-granule content and ANP release in isolated rat hearts was not fully characterized.
p-value: p=<0.001
Atrial natriuretic peptide (ANP) is known to be stored in specific secretory granules of cardiac myocytes. Atrial distension seems to be the major stimulus for ANP release. In the present study, we have investigated by means of light and electron microscopy and radioimmunoassay (RIA) left atrial ANP-granule content and ANP release of isolated rat heart, perfused with different left atrial pressures (5, 10, 15 and 20cm H2O). Left atrial ANP-granule content was significantly reduced when left atrial pressure was elevated by perfusion volume expansion. There were no significant differences in ANP-granule content after perfusion with identical pressures over different time periods (20min or 60min). Measurement of ANP in the coronary effluent by RIA showed a significant pressure-dependent increase of ANP release, except for left atrial pressure elevation from 15 to 20cm H2O, which did not result in a further increase of ANP release.
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Haug et al. (1991) studied Healthy (n=36). Left atrial pressure elevation vs. Non-perfused controls and lower pressures was evaluated on Left atrial ANP-granule content and ANP release (p=<0.001). Elevation of left atrial pressure from 5 to 15 cm H2O in isolated perfused rat hearts significantly reduced ANP-granule content and increased ANP release (p<0.001).
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