Key result
Increasing the atrial driving rate to 200 beats/min significantly increased the release of atrial natriuretic peptide from the isolated right atrium compared to 100 beats/min (2250 vs 1630 pg/ml).
Population
Isolated right atrium cross-circulated with heparinized arterial blood of donor dogs (n=4)
Comparison
Electrical pacing at an increased rate of 200… vs Spontaneous sinoatrial rate, pacing at 100…
Design
Preclinical
Authors
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Does not inform clinical rate management; leaves open rate-dependent ANP effects in intact human hearts.
Absolute Event Rate: 2250% vs 1630%
This preclinical study demonstrates that atrial natriuretic peptide is exclusively secreted from the atrium and its release is directly stimulated by increased atrial rate.
Motomura et al. (1988) studied this question. Increased electrical driving rate vs. 100 beats/min was evaluated on ANP concentration in venous blood leaving the right atrium. Increasing the atrial driving rate to 200 beats/min significantly increased the release of atrial natriuretic peptide from the isolated right atrium compared to 100 beats/min (2250 vs 1630 pg/ml).
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