Population
Permissive cells transfected with the RNA pregenome of duck hepatitis B virus (an avian hepadnavirus)
Design
Preclinical
Authors
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Hypothesis-generating for hepadnaviral replication in animals; leaves open human HBV relevance and therapeutic implications.
The RNA pregenome of hepadnaviruses can express all proteins required for DNA synthesis and serve as a template for reverse transcription to establish a productive infection.
Huang et al. (1991) studied this question.
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