March 1, 1996Hypertension

Renal Sympathetic Neural Mechanisms as Intermediate Phenotype in Spontaneously Hypertensive Rats

View Full Paper

Ask AI

Bookmark

Population

Borderline hypertensive rats, two-kidney one clip Goldblatt-hypertensive rats, and a backcross population

Comparison

8% NaCl diet vs 1% NaCl diet

Design

Preclinical

Follow-up

12 weeks

Authors

GDGerald F. DiBonaGeneral Cardiology SJSusan Y. JonesUniversity of Iowa LSLinda L. SawinUniversity of Iowa

Discussion

Member takes

Implication

Renal sympathetic mechanisms may drive genetic hypertension in SHR models; leaves open translation to human therapy.

Structured PICO

Population

Borderline hypertensive rats (F1 cross between spontaneously hypertensive rat [SHR] and normotensive Wistar-Kyoto [WKY] rat), two-kidney one clip Goldblatt-hypertensive rats, and a backcross population (F1 x WKY)

Intervention

8% NaCl diet

Comparator

1% NaCl diet

Outcome

Renal sympathetic neural mechanisms (enhanced renal sympathoexcitation with air-jet stress and enhanced renal sympathoinhibition with guanabenz) and their cosegregation with hypertensionsurrogate

Renal sympathetic neural mechanisms cosegregate with hypertension in a genetic rat model, supporting their role as an intermediate phenotype in spontaneously hypertensive rats.

Cite This Study

DiBona et al. (1996) studied this question.

synapsesocial.com/papers/6a71038b75498292b70a7fe2 https://doi.org/10.1161/01.hyp.27.3.626

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Renal Sympathetic Neural Mechanisms as Intermediate Phenotype in Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Renal Sympathetic Neural Mechanisms as Intermediate Phenotype in Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider