Population
Rats divided into sham, depression, myocardial infarction, and post-MI depression groups.
Comparison
Post-myocardial infarction depression model. vs Sham, depression alone, and myocardial…
Design
Preclinical
Authors
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No immediate clinical implications; extends preclinical evidence linking post-MI depression to myocardial apoptosis.
In a rat model, post-MI depression is associated with increased myocardial pro-apoptotic signaling (Bax:Bcl-2 ratio), suggesting a pathophysiological link between depression and adverse post-MI outcomes.
Wang et al. (2013) studied this question.
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