Why the study?
Does escitalopram reduce myocardial apoptosis and infarct size in a rat model of depression with myocardial ischemia/reperfusion?
Population
Rat model of depression during myocardial ischemia/reperfusion
Comparison
Escitalopram administered by gavage for 21 days… vs Depression group and Depression with myocardial…
Design
Preclinical, Rats were divided randomly into 3 groups
Follow-up
21 days
Authors
Loading...
May warrant preclinical follow-up but does not support clinical use; leaves open translation to human depression-MI models.
Does escitalopram reduce myocardial apoptosis and infarct size in a rat model of depression with myocardial ischemia/reperfusion?
Escitalopram reduces myocardial infarct size and apoptosis in a rat model of depression with myocardial ischemia/reperfusion, suggesting a potential direct cardioprotective mechanism.
Wang et al. (2014) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: