Why the study?
Does systemic heparin or synthetic antithrombin reduce acute platelet deposition on endovascular stents in a baboon arteriovenous shunt model?
Population
Baboons with chronic exteriorized arteriovenous silicone rubber shunts incorporating 3-mm expanded…
Comparison
Balloon-expandable or self-expandable… vs Untreated control ePTFE grafts without stents
Design
Preclinical
Follow-up
1 hour
Authors
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Stent-induced platelet deposition resists heparin in this baboon model; leaves open optimal antithrombotic strategies for human endovascular procedures.
Does systemic heparin or synthetic antithrombin reduce acute platelet deposition on endovascular stents in a baboon arteriovenous shunt model?
Endovascular stents cause significant acute platelet deposition that is resistant to systemic heparin in a baboon model.
Krpski et al. (1990) studied this question.
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